Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis. | Zendy

M. R. El-Khatib | Zendy; J. L. Chason | Zendy; A. Martin Lerner | Zendy

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Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis.

Author(s) -

M. R. El-Khatib,

J. L. Chason,

A. Martin Lerner

Publication year - 1979

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.59.2.412

Subject(s) - medicine , myocarditis , coxsackievirus , group b , group a , aneurysm , complication , cardiology , enterovirus , virulence , pathology , immunology , virus , surgery , biology , biochemistry , gene

Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurrently matched control mice developed aneurysms. Ventricular aneurysm is a suggested but previously undocumented complication of murine, and possibly human necrotizing transmural coxsackievirus myocarditis.

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