The extraction of thallium-201 by the myocardium. | Zendy

H. F. H. Weich | Zendy; H. William Strausś | Zendy; Bertram Pitt | Zendy

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The extraction of thallium-201 by the myocardium.

Author(s) -

H. F. H. Weich,

H. William Strausś,

Bertram Pitt

Publication year - 1977

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.56.2.188

Subject(s) - thallium , medicine , propranolol , blood flow , extraction (chemistry) , strophanthin , cardiology , extraction ratio , tracer , chromatography , chemistry , ouabain , sodium , inorganic chemistry , physics , organic chemistry , nuclear physics

The concentration of thallium-201 in the myocardium immediately following injection of tracer is the result of both blood flow delivering tracer to the heart and extraction by the myocardium. In these studies, the extraction of thallium-201 by the canine myocardium was determined as a function of heart rate, coronary blood flow, hypoxia, changes in pH, and following administration of propranolol, insulin, and strophanthin. Under basal conditions, extraction fraction measured 88 +/- 2.1%, following pacing to a rate of 195 beats/min extraction fraction remained unchanged at 88.5%. Similar results were found with changes in pH, propranolol, insulin, and strophanthin. Hypoxia caused a significant decrease in extraction fraction to 77.9%. When coronary blood flow was increased in excess of demands by drugs, extraction fraction fell logarithmically.

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