Open AccessEffects of procainamide and quinidine sulfate in the Wolff-Parkinson-White syndrome.
Author(s) -
T. Duncan Sellers,
R. W. F. Campbell,
Thomas M. Bashore,
John J. Gallagher
Publication year - 1977
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.55.1.15
Subject(s) - procainamide , quinidine , medicine , anesthesia , atrial fibrillation , cardiology
Thirty-three patients with Wolff-Parkinson-White syndrome were studied electrophysiologically before and after administration of intravenous procainamide and oral quinidine sulfate. Procainamide prolonged the shortest R-R (SRR) interval between two consecutive pre-excited beats during atrial fibrillation 20-70 msec in 15 of 21 patients with no change observed in 6 of 21 patients. Quinidine sulfate prolonged the SRR 20-170 msec in all 16. In 14 of 18 patients where procainamide and quinidine were comparable, quinidine prolonged the SRR 30-100 msec more than procainamide.
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