The Relationship of Serum Lipoproteins to Atherosclerosis in the Cholesterol-Fed Alloxanized Rabbit | Zendy

Frank T. Pierce | Zendy

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The Relationship of Serum Lipoproteins to Atherosclerosis in the Cholesterol-Fed Alloxanized Rabbit

Author(s) -

Frank T. Pierce

Publication year - 1952

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.5.3.401

Subject(s) - cholesterol , medicine , endocrinology , rabbit (cipher) , alloxan , arteriosclerosis , lagomorpha , blood lipids , diabetes mellitus , statistics , mathematics

The alloxanized rabbit fed cholesterol develops extreme hyperlipemia and hypercholesteremia and yet develops a lesser degree of atherosclerosis than does the normal animal fed cholesterol. The concentrations of the Sf 12-30 and Sf 20-30 classes of lipoproteins correlate well with atherosclerosis as finally observed in the alloxanized rabbit, whereas both free and total serum cholesterol correlate negatively with atherosclerosis. In the alloxan-diabetic rabbit, the serum cholesterol is principally carried in the Sf 80-100 and greater classes of lipoproteins, and a metabolic block in the conversion of these lipoproteins to those of Sf 40 and less can be demonstrated.

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