An Evaluation of Replacement Fluids in Laboratory Animals following Control Hemorrhage | Zendy

AD Morrison | Zendy; John S. Lundy | Zendy; Hiram E. Essex | Zendy

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An Evaluation of Replacement Fluids in Laboratory Animals following Control Hemorrhage

Author(s) -

AD Morrison,

John S. Lundy,

Hiram E. Essex

Publication year - 1952

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.5.2.208

Subject(s) - medicine , isotonic saline , whole blood , saline , dextran , albumin , guinea pig , isotonic , plasmoid , physiology , surgery , anesthesia , biochemistry , biology , magnetic reconnection , physics , quantum mechanics , magnetic field

Solutions of Dextran Ph, Plasmoid, Periston and isotonic saline were compared with serum albumin and whole blood to determine the efficacy of the former as blood substitutes. Rats, guinea pigs and dogs were used as experimental animals. Dextran Ph, Plasmoid and Periston were found to be less satisfactory than whole blood, since 50 to 80 per cent of the rats and guinea pigs survived following their use compared with 100 per cent survival when whole blood was given. There was, however, 100 per cent mortality of the animals when a blood substitute was not given.

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