Effect of Carbon Monoxide Exposure on Intermittent Claudication | Zendy

Wilbert Aronow | Zendy; Edward A. Stemmer | Zendy; MICHAEL W. ISBELL | Zendy

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Effect of Carbon Monoxide Exposure on Intermittent Claudication

Author(s) -

Wilbert Aronow,

Edward A. Stemmer,

MICHAEL W. ISBELL

Publication year - 1974

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.49.3.415

Subject(s) - medicine , carbon monoxide , carboxyhemoglobin , intermittent claudication , claudication , breathing , cardiology , anesthesia , ventilation (architecture) , vascular disease , arterial disease , chemistry , biochemistry , mechanical engineering , engineering , catalysis

The effect of breathing 50 ppm of carbon monoxide for two hours versus compressed, purified air for two hours on intermittent claudication was evaluated in ten men in a double-blind study. The mean venous carboxyhemoglobin level insignificantly decreased from 1.12% to 0.90% after breathing compressed, purified air but significantly increased from 1.08% to 2.77% after breathing carbon monoxide (P < 0.001). The mean exercise time until the onset of intermittent claudication insignificantly increased from 169 sec to 173 sec after breathing compressed, purified air but significantly decreased from 174 sec to 144 sec after breathing carbon monoxide (P < 0.001). Breathing 50 ppm of carbon monoxide for 2 hr significantly aggravated intermittent claudication of the calf or thigh due to angiographically documented occlusive arterial disease.

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