Relation between Digoxin Arrhythmias and ABO Blood Groups | Zendy

Boston Collaborative Drug Surveillance Program | Zendy

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Relation between Digoxin Arrhythmias and ABO Blood Groups

Author(s) -

Boston Collaborative Drug Surveillance Program

Publication year - 1972

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.45.2.352

Subject(s) - medicine , digoxin , abo blood group system , relative risk , confidence interval , cardiology , heart failure

In a series of 1,080 consecutively monitored patients who received digoxin, arrhythmias attributed to the drug were observed in 144 cases (13.3%). The proportion of arrhythmias among 510 patients with blood group O was 10%, while for the 570 patients of groups A, B, and AB (non-O), it was 16.3% (P < 0.002). The point estimate of relative risk for non-O patients relative to group O patients with 1.7, with 95% confidence limits of 1.2 and 2.5, and the increase in the risk was most prominent between the ages of 50 and 69 years.

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