Effects of Ouabain on Myocardial Potassium and Sodium Balance in Man | Zendy

F. James Brennan | Zendy; John McCans | Zendy; Miguel A. Chiong | Zendy; John O. Parker | Zendy

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Effects of Ouabain on Myocardial Potassium and Sodium Balance in Man

Author(s) -

F. James Brennan,

John McCans,

Miguel A. Chiong,

John O. Parker

Publication year - 1972

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.45.1.107

Subject(s) - medicine , ouabain , cardiology , digitalis , inotrope , heart rate , blood pressure , potassium , sodium , hemodynamics , diastole , stroke volume , cardiac index , cardiac output , heart failure , chemistry , organic chemistry

Myocardial electrolyte balance and hemodynamics were studied in 14 patients before and after the administration of ouabain. The drug caused a significant loss of potassium from the myocardium. This was accompanied by a significant positive inotropic response, indicated by an increase in the rate of rise of left ventricular pressure and systolic ejection-rate index. Heart rate, cardiac output, left ventricular end-diastolic pressure, brachial artery pressure, and left ventricular stroke-work index remained unchanged. These observations in man are compatible with those theories of digitalis action which associate inotropic effect with the inhibition of membrane sodium- and potassium-activated adenosine triphosphatase.

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