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The effects of carotid sinus nerve (CSN) stimulation were studied at rest and during a mild level of supine bicycle exercise in seven patients in whom CSN stimulators had been implanted for the treatment of angina pectoris. At rest, CSN stimulation produced a fall in mean arterial pressure (MAP) averaging 23% and an 8% decrease in cardiac output (CO). Total peripheral resistance (TPR) fell by 14% and forearm vascular resistance (FVR) by 16%. During exercise, MAP fell 16%, but no significant change occurred in CO. Thus, the fall in MAP could be attributed to a reflexly induced decrease in peripheral vascular resistance. Only small decreases occurred in heart rate. No changes in venous tone, central venous pressure, or the maximum transverse end-diastolic diameter of the heart were produced by stimulation either at rest or during exercise. Thus, at rest, CSN stimulation reduces MAP by reflexly decreasing both vascular resistance and CO; during exercise, the diminution in CO no longer occurs. Finally, the venous system does not appear to participate in reflexes activated by CSN stimulation.

Circulatory Effects of Electrical Stimulation of the Carotid Sinus Nerves in Man