The Effect of Intravenously Administered Digoxin on Water and Electrolyte Excretion and on Renal Functions | Zendy

Saul J. Färber | Zendy; John D. Alexander | Zendy; Edmund D. Pellegrino | Zendy; David P. Earle | Zendy

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The Effect of Intravenously Administered Digoxin on Water and Electrolyte Excretion and on Renal Functions

Author(s) -

Saul J. Färber,

John D. Alexander,

Edmund D. Pellegrino,

David P. Earle

Publication year - 1951

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.4.3.378

Subject(s) - diuresis , medicine , digoxin , renal function , heart failure , central venous pressure , hemodynamics , cardiology , blood pressure , kidney , diuretic , edema , heart rate , anesthesia

Digoxin causes a prompt and considerable water and salt diuresis in congestive heart failure. This may occur with little or no change in renal hemodynamics, but usually is associated with decreased venous pressure. At times, increased glomerular filtration rate may contribute to the diuresis. In patients with noncardiac edema and without edema, Digoxin may also initiate a slight but definite sodium diuresis. This effect is not as great as in patients with congestive heart failure and apparently is not associated with changes in renal hemodynamics, cardiac output or venous pressure.

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