The Effect of Carbon Tetrachloride Poisoning on Serum Lipoproteins Associated with Atherosclerosis

Carbon tetrachloride was injected into normal rabbits and the levels of Sf 3-12, 12-20, and 20-40 classes of lipoproteins were determined during the course of these injections. A marked increase in concentration of these three classes of lipoproteins occurred during the administration of carbon tetrachloride. After the cessation of this drug, the lipoproteins of largest Sf rate returned to normal first with those of lower Sf rate returning to normal levels in the order of decreasing Sf rates. Rabbits fed cholesterol were also injected with carbon tetrachloride, and their lipoproteins continued to increase after cessation of this drug.