The Deposition of Digitoxin in the Tissues of the Rat After Parenteral Injection | Zendy

René Bine | Zendy; Meyer Friedman | Zendy; Sanford O. Byers | Zendy; CATHARINE BLAND | Zendy

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The Deposition of Digitoxin in the Tissues of the Rat After Parenteral Injection

Author(s) -

René Bine,

Meyer Friedman,

Sanford O. Byers,

CATHARINE BLAND

Publication year - 1951

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.4.1.105

Subject(s) - digitoxin , medicine , kidney , endocrinology , lung , excretion , skeletal muscle , pharmacology , digoxin , heart failure

Quantitative studies regarding the fate of parenterally injected digitoxin in the rat were made by assaying extracts of rat tissue by the embryonic duck heart method. The concentration of digitoxin found in heart muscle was similar to that found in lung and kidney and greater than the concentration in skeletal muscle. The greatest amount was found in the liver and suggested the importance of this organ in the excretion or destruction of digitoxin.

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