Open AccessFocal Lipid Lesions in Blood Vessels due to Erythrocytes and Platelets
Author(s) -
P.J. Barnard,
David H. Thompson
Publication year - 1966
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.33.5.744
Subject(s) - medicine , pathogenesis , platelet , thrombosis , lysis , pathology , blood lipids , red blood cell , cholesterol , immunology
Experiments on goats and rabbits living on a normal diet demonstrated that the lipid associated with organizing thrombi became concentrated in fibrosed focal lesions of blood vessels. The lipid that appeared during organization of lysed erythrocytes underwent changes similar to those of lipid in thrombi. From this it was concluded that what red cells there were in the thrombi contributed to the total lipid present.These observations are pertinent to the pathogenesis of atherosclerosis, because they help to explain the thrombosis characteristically associated with this disease, and how lipid can be delivered to restricted regions of the arterial intima.
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