Hemodynamic Effects of Pargyline in Hypertensive Patients | Zendy

G Onesti | Zendy; Paul Novack | Zendy; Osvaldo Ramirez | Zendy; Albert N. Brest | Zendy; John H. Moyer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Hemodynamic Effects of Pargyline in Hypertensive Patients

Author(s) -

G Onesti,

Paul Novack,

Osvaldo Ramirez,

Albert N. Brest,

John H. Moyer

Publication year - 1964

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.30.6.830

Subject(s) - medicine , pargyline , hemodynamics , renal function , cardiology , peripheral resistance , vascular resistance , renal blood flow , cardiac output , endocrinology , receptor , serotonin

Pargyline exerts its antihypertensive effect via a predominant reduction in peripheral vascular resistance, whereas cardiac output is not altered significantly. The effect on renal blood flow is inconsistent, but a significant reduction in glomerular filtration rate does occur. Therefore the drug should be used with appropriate caution in patients with significant impairment of renal function. The hemodynamic response observed with pargyline is similar to that obtained with other MAO inhibitors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research