The Effect of Priscoline on Peripheral Blood Flow in Normal Subjects and Patients with Peripheral Vascular Disorders

Using the venous occlusion plethysmograph the authors have studied the peripheral circulation of normal subjects and persons with peripheral vascular disease. It is demonstrated that the vasodilating agent Priscoline (2-benzyl-4,5-imidazoline hydrochloride) frequently increases peripheral blood flow to a degree comparable to that produced by either sympathectomy or indirect body heating. In addition, the combined use of plethysmography and a vasodilating procedure is shown to be of value in the diagnosis of peripheral vascular disorders.