Abnormal Cardiac Rhythms Caused by Acetylcholine | Zendy

David Scherf | Zendy; Forris B. Chick | Zendy

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Abnormal Cardiac Rhythms Caused by Acetylcholine

Author(s) -

David Scherf,

Forris B. Chick

Publication year - 1951

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.3.5.764

Subject(s) - medicine , auricular fibrillation , acetylcholine , stimulus (psychology) , cardiology , fibrillation , rhythm , stimulation , vagus nerve , anesthesia , atrial fibrillation , psychology , psychotherapist

The effect of topical administration of acetylcholine on the auricular and ventricular surface of the dog's heart was studied. The experiments show the appearance of variform arrhythmias, particularly auricular fibrillation. The tendency for the development of these arrhythmias is diminished, but not abolished by atropinization. The experiments confirm previous results of the authors according to which auricular flutter is due to a rapid stimulus formation in a center. They help explain the occasional appearance of extrasystoles and paroxysmal tachycardias during vagus stimulation in experimental and clinical observations.

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