Clinical Evaluation of Dicumarinyl Derivatives with a Metabolic Study of the Radioactively Labeled Anticoagulants in Animals | Zendy

ERIC P. HAUSNER | Zendy; CHARLES L. SHAFER | Zendy; Marion Corson | Zendy; O.Douglas Johnson | Zendy; T. T. Trujillo | Zendy; Wright H. Langham | Zendy

Open Access

Clinical Evaluation of Dicumarinyl Derivatives with a Metabolic Study of the Radioactively Labeled Anticoagulants in Animals

Author(s) -

ERIC P. HAUSNER,

CHARLES L. SHAFER,

Marion Corson,

O.Douglas Johnson,

T. T. Trujillo,

Wright H. Langham

Publication year - 1951

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.3.2.171

Subject(s) - medicine , pharmacodynamics , pharmacology , pharmacokinetics

The common use of dicumarinyl derivatives for the treatment of thromboembolic diseases justifies further clinical evaluation of dicumarol and 4,4'-dihydroxydicumarinyl ethyl acetate [Pelentan, Tromexan, 3,3'-carboxymethylenebis (4-hydroxycoumarin) ethyl ester.] The need for a more thorough understanding of the pharmacodynamic action of dicumarinyl anticoagulants has prompted a study of their gross metabolism in animals, using C14-labeled materials.

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