Effects of Inhalation of 100 Per Cent Oxygen on the Pulmonary Blood Volume in Patients with Organic Heart Disease | Zendy

Gerald Glick | Zendy; Bernard F. Schreiner | Zendy; Gerald W. Murphy | Zendy; Paul N. Yu | Zendy

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Effects of Inhalation of 100 Per Cent Oxygen on the Pulmonary Blood Volume in Patients with Organic Heart Disease

Author(s) -

Gerald Glick,

Bernard F. Schreiner,

Gerald W. Murphy,

Paul N. Yu

Publication year - 1963

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.27.4.554

Subject(s) - medicine , anesthesia , blood pressure , blood volume , pulmonary heart disease , inhalation , cardiology , hyperoxia , lung

The effect of breathing 100 per cent oxygen on the pulmonary blood volume, pulmonary arterial pressure, left atrial pressure, and pulmonary vascular distending pressure was studied during cardiac catheterization in eight patients with organic heart disease. In half of the patients, a significant decrease in pulmonary blood volume was observed. This decline in pulmonary blood volume in the face of a decrease or no change in the pulmonary distending pressure is interpreted as evidence for a passive mechanism of action for 100 per cent oxygen.The effects of hyperoxia are compared to those of acetylcholine, which works by actively dilating the pulmonary vascular bed.

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