The Possible Role of Calcium in Excitation-Contraction Coupling of Heart Muscle | Zendy

Chandler McC. Brooks | Zendy; Saul Winegrad | Zendy

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The Possible Role of Calcium in Excitation-Contraction Coupling of Heart Muscle

Author(s) -

Chandler McC. Brooks,

Saul Winegrad

Publication year - 1961

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.24.2.523

Subject(s) - contraction (grammar) , calcium , medicine , excitation–contraction coupling , stimulation , biophysics , muscle contraction , cardiology , endocrinology , biology

The transfer of Ca45 at rest and during contraction has been measured in isolated guinea-pig atria. During contraction, the rate of transfer increases considerably. The increment in the uptake of calcium by the cells of the atria during contraction is closely correlated with the strength of contraction. This relationship is maintained at different frequencies of stimulation and at different concentrations of external calcium.

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