Membrane Excitation in Cardiac Muscle | Zendy

Chandler McC. Brooks | Zendy; Silvio Weidmann | Zendy

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Membrane Excitation in Cardiac Muscle

Author(s) -

Chandler McC. Brooks,

Silvio Weidmann

Publication year - 1961

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.24.2.499

Subject(s) - plateau (mathematics) , repolarization , medicine , membrane potential , resting potential , conductance , biophysics , intracellular , cardiac muscle , membrane , benign early repolarization , electrophysiology , cardiology , microbiology and biotechnology , chemistry , biochemistry , biology , condensed matter physics , physics , mathematical analysis , mathematics , st segment , myocardial infarction

The contributions made during the past 10 years are reviewed. Intracellular recording has made it possible to state absolute values for the cardiac resting potential (90 mv., inside negative to outside) and the "overshoot" during activity (30 mv., inside positive to outside). The surface membrane of a resting fiber is considered to be predominately permeable to K ions. During activity, Na conductance increases and K conductance decreases. The latter process is thought to be essential for explaining the high membrane resistance that is measured during the long-lasting "plateau" found with cardiac muscle. A hypothesis is presented that would account for the termination of the plateau and the beginning of repolarization.

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