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The amount of mitral regurgitation was estimated in 50 patients by an indicator-dilution technic and by the usual clinical, catheterization, operative, and autopsy criteria. There was a good correlation between the two estimates. Patients with significant mitral regurgitation (grade 2 or grade 3) had, with one exception, QR/QF ratios above 0.41. There were at least two instances where the calculated QR/QF was almost certainly falsely high. It seems likely that these discrepancies are related to the presence of an unusually large volume between the pulmonary artery and the femoral artery.

An Appraisal of the Double Indicator-Dilution Method for the Estimation of Mitral Regurgitation in Human Subjects