Plasma Norepinephrine Response to Tilting in Essential Hypertension | Zendy

Roger B. Hickler | Zendy; James T. Hamlin | Zendy; Roe E. Wells | Zendy

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Plasma Norepinephrine Response to Tilting in Essential Hypertension

Author(s) -

Roger B. Hickler,

James T. Hamlin,

Roe E. Wells

Publication year - 1959

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.20.3.422

Subject(s) - medicine , norepinephrine , baroreceptor , essential hypertension , endocrinology , peripheral , pathophysiology of hypertension , reflex , blood pressure , cardiology , anesthesia , heart rate , dopamine

A significant increase in the plasma concentration of norepinephrine on tilting 19 normal subjects from the horizontal to 60° upright is described. Evidence that this represents an increased neuroadrenergic activity to maintain cerebral circulation despite the peripheral pooling of blood has previously been reported. When 9 subjects with severe essential hypertension were similarly tilted, the rise in plasma norepinephrine concentration was insignificant. This may indicate a diminished neuroadrenergic activity in essential hypertension due to compensatory reflexes from the baroreceptor regions.

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