Open AccessEffects of Intravenous Administration of Fibrinolysin (Plasmin) in Man
Author(s) -
Kenneth Μ. Moser
Publication year - 1959
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.20.1.42
Subject(s) - medicine , fibrinolysin , plasmin , pharmacology , administration (probate law) , intensive care medicine , biochemistry , enzyme , chemistry , political science , law
The potentiality of dissolving clots has aroused great interest in fibrinolysin (plasmin) as a therapeutic agent in thromboembolism. In this paper the effects of intravenous administration of purified fibrinolysin in man are reported, with special emphasis upon systemic toxicity and alterations in clotting factors and fibrinolytic activity. This information is necessary for the evaluation of this agent for clinical purposes.
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