The Renal Excretion of Digitoxin in the Normal Subject after Single and Continuous Administration of the Drug | Zendy

Meyer Friedman | Zendy; René Bine | Zendy; Sanford O. Byers | Zendy; CATHERINE BLAND | Zendy

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The Renal Excretion of Digitoxin in the Normal Subject after Single and Continuous Administration of the Drug

Author(s) -

Meyer Friedman,

René Bine,

Sanford O. Byers,

CATHERINE BLAND

Publication year - 1950

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.2.5.749

Subject(s) - digitoxin , medicine , urine , excretion , endocrinology , kidney , digitalis , renal physiology , drug , pharmacology , digoxin , heart failure

By employing the embryonic duck heart method to assay digitoxin quantitatively in extracts of human urine, it was found that, contrary to previous opinion, a large percentage of ingested or in-injected digitoxin is excreted via the kidney in a physiologically active state. Approximately 40 per cent of a digitalizing dose (1.2 mg.) is excreted over a period of 12 to 24 days. The average rate of renal excretion in theoretically digitalized normal young individuals was found to vary from 30 to 50 &mgr;g. of digitoxin per day, while those showing signs or symptoms of overdosage excreted significantly greater amounts of digitoxin.

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