Production of Experimental Cholesterol-Induced Atherosclerosis in Chicks with Minimal Hypercholesterolemia and Organ Lipidosis | Zendy

Jeremiah Stamler | Zendy; Louis N. Katz | Zendy; C. Bolene | Zendy

Open Access

Production of Experimental Cholesterol-Induced Atherosclerosis in Chicks with Minimal Hypercholesterolemia and Organ Lipidosis

Author(s) -

Jeremiah Stamler,

Louis N. Katz,

C. Bolene

Publication year - 1950

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.2.5.705

Subject(s) - medicine , cholesterol , cottonseed oil , arteriosclerosis , aorta , pathogenesis , endocrinology , familial hypercholesterolemia , cottonseed , fatty streak , thoracic aorta , biology , food science

Feeding chicks a mash enriched with 0.25 per cent cholesterol plus 5 per cent cottonseed oil induces a minimal sustained hypercholesterolemia. After 35 weeks of this regimen, birds exhibited a high incidence of gross cholesterol-induced atherosclerosis, particularly prominent in the thoracic aorta. The presence of atherosclerosis in these chicks with minimal diet-induced hypercholesterolemia lends further experimental support to the concept of the relationship of cholesterol in general, and exogenous cholesterol in particular, to the pathogenesis of human atherosclerosis.

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