A Synthetic Anticoagulant: A Polysulfuric Acid Ester of Polyanhydromannuronic Acid (Paritol) | Zendy

C. W. SORENSON | Zendy; Irving S. Wright | Zendy

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A Synthetic Anticoagulant: A Polysulfuric Acid Ester of Polyanhydromannuronic Acid (Paritol)

Author(s) -

C. W. SORENSON,

Irving S. Wright

Publication year - 1950

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.2.5.658

Subject(s) - medicine , heparin , anticoagulant , prothrombin time , clotting time , pharmacology , anesthesia , coagulation , surgery

The effects of the use of Paritol administered intravenously to 35 individuals are herein reported. This synthetic anticoagulant produces a prolongation of the clotting time similar to that produced by heparin but of longer duration, if appropriate dosage is used. As with heparin, at therapeutic clotting time levels, the prothrombin time is slightly prolonged. Certain untoward effects have been noted and are described. Further studies with Paritol appear justified in order to evaluate its usefulness as a rapidly acting anticoagulant.

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