A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs | Zendy

Harriet P. Dustan | Zendy; Gordon R. Cumming | Zendy; A. C. Corcoran | Zendy; Irvine H. Page | Zendy

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A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs

Author(s) -

Harriet P. Dustan,

Gordon R. Cumming,

A. C. Corcoran,

Irvine H. Page

Publication year - 1959

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.19.3.360

Subject(s) - chlorothiazide , medicine , vasomotor , blood pressure , cardiology , mechanism (biology) , anesthesia , diuretic , philosophy , epistemology

Chlorothiazide decreases plasma volume, heart size, and cardiac output. The oligemia stimulates vasomotor tone; this tends to maintain arterial pressure because chronic arterial hypertension is characteristically self-sustaining and homeostatic. This oligemic stimulation of vasomotor tone results in increased sensitivity to the antihypertensive effect of drugs depressing or blocking vasomotor function.

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