Open AccessEffects of Chlorothiazide on Specific Renal Functions in Hypertension
Author(s) -
A. C. Corcoran,
Cathel A. Macleod,
Harriet P. Dustan,
Irvine H. Page
Publication year - 1959
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.19.3.355
Subject(s) - chlorothiazide , medicine , diuretic , endocrinology , renal function , reabsorption , sodium , renal sodium reabsorption , urea , kidney , biochemistry , chemistry , organic chemistry
Oral administration of chlorothiazide depresses glomerular filtration, increases blood urea, maintains sodium output in the face of decreased filtered sodium load, and paradoxically for a diuretic, in these and in tests done shortly after intravenous administration, increases the efficiency of water reabsorption.
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