Open AccessSynthesis and Properties of Angiotonin
Author(s) -
F. Merlin Bumpus,
Hans Peter Schwarz,
Irvine H. Page
Publication year - 1958
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.17.4.664
Subject(s) - medicine , histidine , amino acid , leucine , enzyme , stereochemistry , biochemistry , chemistry
Angiotonin has been shown to be formed by a converting enzyme in blood by the splitting off of the 2 amino acids histidine and leucine from the inactive decapeptide (asp-arg-val-tyr-ileu-his-prol-phe-his-leuc). The synthesis of the active octapeptide is described and its pharmacologic resemblance to the natural product is demonstrated.
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