Antibodies to Renin as Proof of the Pathogenesis of Sustained Renal Hypertension | Zendy

G. E. Wakerlin | Zendy

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Antibodies to Renin as Proof of the Pathogenesis of Sustained Renal Hypertension

Author(s) -

G. E. Wakerlin

Publication year - 1958

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.17.4.653

Subject(s) - medicine , renin–angiotensin system , plasma renin activity , titer , pathogenesis , antiserum , endocrinology , antibody , blood pressure , immunology

Antirenin to hog renin produced in the dog neutralizes the acute pressor effect of dog as well as hog renin. A course of intramuscular injections of hog renin in chronic renal hypertensive dogs produces an antihypertensive effect which is correlated with the antirenin titers of the plasma. Passive transfer of high titer homologous antiserum to hog renin produces an antihypertensive effect in chronic renal hypertensive dogs which is correlated with the antirenin titer. The results suggest a pathogenetic role for renin in experimental renal hypertension in the dog.

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