Serum Cholesterol in Pentolinium -Treated Arterial Hypertension | Zendy

Harold H. Orvis | Zendy; Irene G. Tamagna | Zendy; John M. Evans | Zendy

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Serum Cholesterol in Pentolinium -Treated Arterial Hypertension

Author(s) -

Harold H. Orvis,

Irene G. Tamagna,

John M. Evans

Publication year - 1958

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.17.2.176

Subject(s) - medicine , postprandial , blood pressure , placebo , cholesterol , blood lipids , endocrinology , alternative medicine , pathology , insulin

Serum lipids were serially determined in 11 patients receiving pentolinium therapy to evaluate changes secondary to blood pressure effects. Substantial reduction in total Cholesterol was observed, which in some cases was independent of the hypotensive effect of the drug. Fat absorption, studied in 6 patients, revealed diminished postprandial lipemia in each as compared to placebo determinations. However, few patients showed appreciable weight change during a year of therapy. The evidence suggests that the serum lipid changes secondary to pentolinium administration are due to a qualitative change in fat absorption.

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