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Results of Prolonged Treatment with Pentolinium Tartrate
Author(s) -
Edward D. Freis,
Ilse M. Wilson
Publication year - 1956
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.13.6.856
Subject(s) - hydralazine , medicine , blockade , blood pressure , tartrate , anesthesia , receptor , inorganic chemistry , chemistry
A series of 96 patients with severe hypertension has been treated with pentolinium tartrate for an average period of 12 months. Seventeen patients died. Therapy was more effective in arresting changes in the optic fundi and in the heart than in the kidneys. Various combinations of hypotensive agents were tested and it was concluded that in general the combination of pentolinium tartrate, Rauwolfia and hydralazine resulted in the greatest reduction of blood pressure with the least degree of side effects due to ganglionic "blockade."

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