A Controlled Study of the Effect of Intermittent Heparin Therapy on the Course of Human Coronary Atherosclerosis | Zendy

Hyman Engelberg | Zendy; R Kühn | Zendy; Michael A. Steinman | Zendy

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A Controlled Study of the Effect of Intermittent Heparin Therapy on the Course of Human Coronary Atherosclerosis

Author(s) -

Hyman Engelberg,

R Kühn,

Michael A. Steinman

Publication year - 1956

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.13.4.489

Subject(s) - medicine , heparin , myocardial infarction , placebo , coronary atherosclerosis , placebo group , saline , coronary heart disease , cardiology , pathology , alternative medicine

Heparin, 200 mg. subcutaneously, was administered twice weekly to a group of 105 patients with known previous myocardial infarction. A comparable control group of 117 individuals received saline placebos. Over a two-year period, there were 21 deaths due to cardiovascular disease in the placebo group, 4 cardiovascular deaths in the heparin group. The observed differences in deaths between the two groups is statistically significant, p < .01. The results indicate that heparin, in the dosage and manner administered, retards the progress of atherosclerotic disease in patients with coronary atherosclerosis.

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