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Focal cooling of the exposed ventricle of the dog, beating at high rates, elicits ventricular fibrillation within a few seconds. The effect of this mode of cooling on hearts pre-treated with prostigmine or acetylcholine is studied. These compounds do not prevent ventricular fibrillation, but on the contrary some observations show that they enhance its appearance.

Influence of Prostigmine and Acetylcholine on Ventricular Fibrillation Elicited by Focal Cooling