Corticotropin (ACTH) in Heart Disease: Its Paradoxical Effect on Sodium Excretion in Resistant Congestive Failure | Zendy

AUGUSTO A. CÁMARA | Zendy; F.R. Schemm | Zendy

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Corticotropin (ACTH) in Heart Disease: Its Paradoxical Effect on Sodium Excretion in Resistant Congestive Failure

Author(s) -

AUGUSTO A. CÁMARA,

F.R. Schemm

Publication year - 1955

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.11.5.702

Subject(s) - medicine , diuresis , heart failure , refractory (planetary science) , edema , cardiology , pulmonary edema , diuretic , disease , anesthesia , endocrinology , kidney , lung , physics , astrobiology

Since the spring of 1952 we have undertaken a clinical trial of corticotropin in 21 cardiac patients with resistant edema. Of these, there were eight with arteriosclerotic, eight with chronic rheumatic, and three with hypertensive heart disease, while two had cor pulmonale. Beneficial results were obtained in 17, or 81 per cent of the cases. These consisted of a spontaneous diuresis either during corticotropin administration or after its withdrawal, or an alteration of response to mercurials, the patients subsequently responding favorably, whereas they had previously been completely refractory to the mercurial diuretics.

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