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The metabolic, hemodynamic and pathologic effects of hemorrhagic shock on the hearts of intact dogs have been studied, using the technique of venous catheterization of the coronary sinus. Metabolic studies demonstrated an alteration in the pattern of myocardial carbohydrate metabolism during shock and evidence for a relative myocardial oxygen deficiency. Subendocardial hemorrhage or necrosis was found in the left ventricles of some of the dogs.

Effects of Hemorrhagic Shock on the Heart and Circulation of Intact Dogs