Open AccessShear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty
Author(s) -
Jolanda J. Wentzel,
Jeroen Kloet,
Ivan Andhyiswara,
Jan A. Oomen,
Johan C.H. Schuurbiers,
Bart J.G.L. de Smet,
Mark J. Post,
Dominique P.V. de Kleijn,
Gerard Pasterkamp,
Cornelius Borst,
Cornelis J. Slager,
Rob Krams
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.104.1.91
Subject(s) - medicine , angioplasty , balloon , shear stress , cardiology , vascular wall , mechanics , physics
Constrictive vascular remodeling (VR) is the most significant component of restenosis after balloon angioplasty (PTA). Whereas in physiological conditions VR is associated with normalization of shear stress (SS) and wall stress (WS), after PTA the role of SS and WS in VR is unknown. Furthermore, whereas matrix metalloproteinase inhibition (MMPI) has been shown to modulate VR after PTA, its effect on the SS and WS control mechanisms after PTA is unknown.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom