Statins Alter Smooth Muscle Cell Accumulation and Collagen Content in Established Atheroma of Watanabe Heritable Hyperlipidemic Rabbits | Zendy

Yoshihiro Fukumoto | Zendy; Peter Libby | Zendy; Elena Rabkin | Zendy; Christopher C. Hill | Zendy; Makoto Enomoto | Zendy; Yasuhiko Hirouchi | Zendy; Masashi Shiomi | Zendy; Masanori Aikawa | Zendy

Open Access

Statins Alter Smooth Muscle Cell Accumulation and Collagen Content in Established Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

Author(s) -

Yoshihiro Fukumoto,

Peter Libby,

Elena Rabkin,

Christopher C. Hill,

Makoto Enomoto,

Yasuhiko Hirouchi,

Masashi Shiomi,

Masanori Aikawa

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.103.7.993

Subject(s) - fluvastatin , pravastatin , atheroma , statin , in situ hybridization , endocrinology , medicine , ex vivo , rosuvastatin , hmg coa reductase , in vivo , cholesterol , chemistry , gene expression , reductase , biology , biochemistry , simvastatin , enzyme , microbiology and biotechnology , gene

Acute coronary syndromes often result from rupture of vulnerable plaques. The collagen content of plaques probably regulates their stability. This study tested whether HMG-CoA reductase inhibitors (statins) alter interstitial collagen gene expression or matrix metalloproteinase (MMP) levels in rabbit atheroma.

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