Open AccessDifferential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure
Author(s) -
Syed Haq,
Gabriel Choukroun,
Hae Sook Lim,
Kevin Tymitz,
Federica del Monte,
Judith K. Gwathmey,
Luanda Grazette,
Ashour Michael,
Roger J. Hajjar,
Thomas Force,
Jeffery D. Molkentin
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.103.5.670
Subject(s) - calcineurin , protein kinase b , medicine , heart failure , signal transduction , muscle hypertrophy , gsk 3 , mapk/erk pathway , kinase , protein kinase a , endocrinology , p38 mitogen activated protein kinases , mitogen activated protein kinase , microbiology and biotechnology , biology , transplantation
Left ventricular failure is commonly preceded by a period of hypertrophy. Intriguingly, many of the signaling pathways that have been implicated in the regulation of hypertrophy, including the 3 mitogen-activated protein kinases (MAPKs: extracellular signal-regulated kinase, stress-activated protein kinase, and p38), protein phosphatase, calcineurin, and the protein kinase Akt and its target glycogen synthase kinase-3 (GSK-3), also regulate the apoptotic response.
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