Endothelial Dysfunction and Oxidative Stress During Estrogen Deficiency in Spontaneously Hypertensive Rats | Zendy

Sven Waßmann | Zendy; Anselm T. Bäumer | Zendy; Kerstin Strehlow | Zendy; Martin van Eickels | Zendy; Christian Grohé | Zendy; Katja Ahlbory | Zendy; R. Rösen | Zendy; Michael Böhm | Zendy; Georg Nickenig | Zendy

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Endothelial Dysfunction and Oxidative Stress During Estrogen Deficiency in Spontaneously Hypertensive Rats

Author(s) -

Sven Waßmann,

Anselm T. Bäumer,

Kerstin Strehlow,

Martin van Eickels,

Christian Grohé,

Katja Ahlbory,

R. Rösen,

Michael Böhm,

Georg Nickenig

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.103.3.435

Subject(s) - medicine , oxidative stress , endothelial dysfunction , estrogen , endocrinology

Postmenopausal estrogen deficiency is associated with an increased cardiovascular risk, hypertension, and oxidative stress. Angiotensin type 1 (AT(1)) receptor regulation is involved in the pathogenesis of atherosclerosis. To characterize vascular function, oxidative stress, and AT(1) receptor regulation during estrogen deficiency, ovariectomized spontaneously hypertensive rats (SHR) were investigated in comparison with sham-operated animals and with ovariectomized rats receiving estrogen replacement therapy with 17beta-estradiol.

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