Chlamydia pneumoniae Infection in Circulating Human Monocytes Is Refractory to Antibiotic Treatment | Zendy

Jens Gieffers | Zendy; Henriette Füllgraf | Zendy; Jürgen Jahn | Zendy; Matthias Klinger | Zendy; K. Dalhoff | Zendy; Hugo A. Katus | Zendy; Werner Solbach | Zendy; Matthias Maass | Zendy

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Chlamydia pneumoniae Infection in Circulating Human Monocytes Is Refractory to Antibiotic Treatment

Author(s) -

Jens Gieffers,

Henriette Füllgraf,

Jürgen Jahn,

Matthias Klinger,

K. Dalhoff,

Hugo A. Katus,

Werner Solbach,

Matthias Maass

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.103.3.351

Subject(s) - chlamydia , chlamydophila pneumoniae , chlamydiae , azithromycin , medicine , microbiology and biotechnology , antibiotics , chlamydiaceae , immunology , doxycycline , pathogen , cd14 , immune system , biology

Recovery of the intracellular bacterium Chlamydia pneumoniae from atherosclerotic plaques has initiated large studies on antimicrobial therapy in coronary artery disease. The basic concept that antibiotic therapy may eliminate and prevent vascular infection was evaluated in vitro and in vivo by examining the antibiotic susceptibility of C pneumoniae in circulating human monocytes, which are thought to transport chlamydiae from the respiratory tract to the vascular wall.

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