Open AccessMyocardial Fibrosis in DOCA-Salt Hypertensive Rats
Author(s) -
Fatima Ammarguellat,
Isabelle Larouche,
Ernesto L. Schiffrin
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.103.2.319
Subject(s) - medicine , endocrinology , sirius red , myocardial fibrosis , antagonist , endothelin receptor , endothelin 1 , fibrosis , ventricle , endothelin receptor antagonist , cardiac fibrosis , receptor
To test the hypothesis that endothelin-1 contributes to cardiac fibrosis, cardiac collagen deposition was studied in deoxycorticosterone acetate-salt (DOCA-salt) hypertensive rats, in which the endothelin system is activated. The effects of the ET(A)-selective endothelin receptor antagonist A-127722 were evaluated.
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