Oral Matrix Metalloproteinase Inhibition and Arterial Remodeling After Balloon Dilation | Zendy

Marion J. Sierevogel | Zendy; Gerard Pasterkamp | Zendy; Evelyn Velema | Zendy; Peter P.T. de Jaegere | Zendy; Bart J.G.L. de Smet | Zendy; Jan H. Verheijen | Zendy; Dominique P.V. de Kleijn | Zendy; Cornelius Borst | Zendy

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Oral Matrix Metalloproteinase Inhibition and Arterial Remodeling After Balloon Dilation

Author(s) -

Marion J. Sierevogel,

Gerard Pasterkamp,

Evelyn Velema,

Peter P.T. de Jaegere,

Bart J.G.L. de Smet,

Jan H. Verheijen,

Dominique P.V. de Kleijn,

Cornelius Borst

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.103.2.302

Subject(s) - medicine , matrix metalloproteinase , dilation (metric space) , matrix metalloproteinase 9 , cardiology , mathematics , combinatorics

Inhibition of matrix metalloproteinase (MMP) activity after balloon angioplasty by intraperitoneal injection of batimastat reduces late lumen loss by inhibition of constrictive remodeling. In the present study, we investigated whether the oral MMP inhibitor marimastat inhibits constrictive remodeling in favor of neutral or expansive remodeling.

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