Oxidant Stress and Aspirin-Insensitive Thromboxane Biosynthesis in Severe Unstable Angina | Zendy

Francesco Cipollone | Zendy; Giovanni Ciabattoni | Zendy; Paola Patrignani | Zendy; Massimo Pasquale | Zendy; Domenico Di Gregorio | Zendy; Tonino Bucciarelli | Zendy; Giovanni Davı̀ | Zendy; Franco Cuccurullo | Zendy; Carlo Patrono | Zendy

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Oxidant Stress and Aspirin-Insensitive Thromboxane Biosynthesis in Severe Unstable Angina

Author(s) -

Francesco Cipollone,

Giovanni Ciabattoni,

Paola Patrignani,

Massimo Pasquale,

Domenico Di Gregorio,

Tonino Bucciarelli,

Giovanni Davı̀,

Franco Cuccurullo,

Carlo Patrono

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.102.9.1007

Subject(s) - unstable angina , medicine , aspirin , arachidonic acid , thromboxane b2 , endocrinology , excretion , creatinine , thromboxane a2 , angina , lipid peroxidation , isoprostane , cardiology , ischemia , thromboxane , platelet , oxidative stress , myocardial infarction , biochemistry , chemistry , enzyme

Unstable angina is associated with enhanced lipid peroxidation and reduced antioxidant defenses. We have previously reported aspirin failure in the suppression of enhanced thromboxane (TX) biosynthesis in a subset of episodes of platelet activation in this setting. We tested the hypothesis that the in vivo formation of the F(2)-isoprostane 8-iso-prostaglandin (PG)F(2alpha), a bioactive product of arachidonic acid peroxidation, is enhanced in unstable angina and contributes to aspirin-insensitive TX biosynthesis.

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