Open AccessEffects of a K + Channel Opener to Reduce Transmural Dispersion of Repolarization and Prevent Torsade de Pointes in LQT1, LQT2, and LQT3 Models of the Long-QT Syndrome
Author(s) -
Wataru Shimizu,
Charles Antzelevitch
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.6.706
Subject(s) - nicorandil , long qt syndrome , repolarization , medicine , sotalol , qt interval , torsades de pointes , anti arrhythmia agents , heart block , endocrinology , cardiology , electrocardiography , electrophysiology , atrial fibrillation
This study examines the effects of nicorandil, a K(+) channel opener, on transmural dispersion of repolarization (TDR) and induction of torsade de pointes (TdP) under conditions mimicking the LQT1, LQT2, and LQT3 forms of the congenital long-QT syndrome (LQTS).
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