Noradrenergic Vascular Hyper-Responsiveness in Human Hypertension Is Dependent on Oxygen Free Radical Impairment of Nitric Oxide Activity | Zendy

Giuseppe Lembo | Zendy; Carmine Vecchione | Zendy; Raffaele Izzo | Zendy; Luigi Fratta | Zendy; Dario Fontana | Zendy; Gennaro Marino | Zendy; Giovanni Pilato | Zendy; Bruno Trimarco | Zendy

Open Access

Noradrenergic Vascular Hyper-Responsiveness in Human Hypertension Is Dependent on Oxygen Free Radical Impairment of Nitric Oxide Activity

Author(s) -

Giuseppe Lembo,

Carmine Vecchione,

Raffaele Izzo,

Luigi Fratta,

Dario Fontana,

Gennaro Marino,

Giovanni Pilato,

Bruno Trimarco

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.102.5.552

Subject(s) - medicine , nitric oxide , oxygen , pathophysiology of hypertension , cardiology , blood pressure , organic chemistry , chemistry

Noradrenergic vascular hyper-responsiveness is a hallmark of essential hypertension. To evaluate whether nitric oxide plays a role in the enhanced vascular response to norepinephrine in hypertension, we examined 32 hypertensives and 28 normotensives who were distributed in 3 experimental series.

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