Cardioprotective Mechanism of Ischemic Preconditioning Is Impaired by Postinfarct Ventricular Remodeling Through Angiotensin II Type 1 Receptor Activation | Zendy

Takayuki Miki | Zendy; Tetsuji Miura | Zendy; Akihito Tsuchida | Zendy; Atsushi Nakano | Zendy; Tohru Hasegawa | Zendy; Takayuki Fukuma | Zendy; Kazuaki Shimamoto | Zendy

Open Access

Cardioprotective Mechanism of Ischemic Preconditioning Is Impaired by Postinfarct Ventricular Remodeling Through Angiotensin II Type 1 Receptor Activation

Author(s) -

Takayuki Miki,

Tetsuji Miura,

Akihito Tsuchida,

Atsushi Nakano,

Tohru Hasegawa,

Takayuki Fukuma,

Kazuaki Shimamoto

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.102.4.458

Subject(s) - medicine , valsartan , ventricular remodeling , cardiology , ventricle , cardioprotection , ischemia , myocardial infarction , heart failure , ischemic preconditioning , diazoxide , infarction , angiotensin ii , endocrinology , receptor , blood pressure , insulin

Activation of protein kinase C-linked receptors and subsequent opening of the mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel are crucial in preconditioning (PC). This study examined whether postinfarct ventricular remodeling interferes with the PC mechanism.

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