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Estrogen is cardioprotective of the coronary circulation by mechanisms incompletely understood. This study determined the effect of chronic 17beta-estradiol replacement on dilator responses to acetylcholine and sodium nitroprusside of the isolated coronary microcirculation.

Chronic 17β-Estradiol Replacement Increases Nitric Oxide–Mediated Vasodilation of Guinea Pig Coronary Microcirculation