Open AccessChronic 17β-Estradiol Replacement Increases Nitric Oxide–Mediated Vasodilation of Guinea Pig Coronary Microcirculation
Author(s) -
Loren P. Thompson,
Gerard Pinkas,
Carl P. Weiner
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.4.445
Subject(s) - sodium nitroprusside , medicine , endocrinology , ovariectomized rat , dilator , nitric oxide , vasodilation , estrogen , endothelium , coronary vasodilator , acetylcholine , perfusion
Estrogen is cardioprotective of the coronary circulation by mechanisms incompletely understood. This study determined the effect of chronic 17beta-estradiol replacement on dilator responses to acetylcholine and sodium nitroprusside of the isolated coronary microcirculation.
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