Trypanosoma cruzi –Infected Cardiomyocytes Produce Chemokines and Cytokines That Trigger Potent Nitric Oxide–Dependent Trypanocidal Activity | Zendy

Fabiana S. Machado | Zendy; Gislâine A. Martins | Zendy; Júlio Aliberti | Zendy; Fabíola Mestriner | Zendy; Fernando Q. Cunha | Zendy; João S. Silva | Zendy

Open Access

Trypanosoma cruzi –Infected Cardiomyocytes Produce Chemokines and Cytokines That Trigger Potent Nitric Oxide–Dependent Trypanocidal Activity

Author(s) -

Fabiana S. Machado,

Gislâine A. Martins,

Júlio Aliberti,

Fabíola Mestriner,

Fernando Q. Cunha,

João S. Silva

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.102.24.3003

Subject(s) - trypanosoma cruzi , nitric oxide , medicine , chemokine , chagas disease , nitric oxide synthase , pharmacology , virology , immunology , inflammation , parasite hosting , world wide web , computer science

The pathogenesis of myocarditis that occurs in Trypanosoma cruzi-infected mice is still poorly understood. Therefore, it is important to know the mediators that trigger leukocyte migration to the heart as well as the cellular source of these possible mediators. In this study, we investigated (1) NO synthase (NOS) induction, (2) NO synthesis, (3) trypanocidal activity, and (4) chemokine and cytokine mRNA expression by isolated cardiomyocytes infected with T cruzi.

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