Potential Contribution of a Novel Antifibrotic Factor, Hepatocyte Growth Factor, to Prevention of Myocardial Fibrosis by Angiotensin II Blockade in Cardiomyopathic Hamsters | Zendy

Yoshiaki Taniyama | Zendy; Ryuichi Morishita | Zendy; Hironori Nakagami | Zendy; Atsushi Moriguchi | Zendy; Hiroshi Sakonjo | Zendy; ShokeiKim | Zendy; Kunio Matsumoto | Zendy; Toshikazu Nakamura | Zendy; Jitsuo Higaki | Zendy; Toshio Ogihara | Zendy

Open Access

Potential Contribution of a Novel Antifibrotic Factor, Hepatocyte Growth Factor, to Prevention of Myocardial Fibrosis by Angiotensin II Blockade in Cardiomyopathic Hamsters

Author(s) -

Yoshiaki Taniyama,

Ryuichi Morishita,

Hironori Nakagami,

Atsushi Moriguchi,

Hiroshi Sakonjo,

ShokeiKim,

Kunio Matsumoto,

Toshikazu Nakamura,

Jitsuo Higaki,

Toshio Ogihara

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.102.2.246

Subject(s) - hepatocyte growth factor , medicine , endocrinology , angiotensin ii , fibrosis , plasminogen activator inhibitor 1 , transforming growth factor , blockade , cardiac fibrosis , plasminogen activator , receptor

Because hepatocyte growth factor (HGF) prevented and/or regressed fibrosis in liver and pulmonary injury models, HGF may play an important role in the pathogenesis of fibrotic cardiovascular disease. Because angiotensin (Ang) II significantly decreased local HGF production, we performed (1) in vitro experiments using fibroblasts and (2) administration of an ACE inhibitor (temocapril) and an Ang II type 1 receptor antagonist (CS-866) to cardiomyopathic hamsters.

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